Cochrane Review Group

Pain, Palliative and Supportive Care

147 systematic reviews in Pain, Palliative and Supportive Care ask 1,751 questions. 20.6% have no studies to answer them, 35.7% rest on very low certainty evidence and 17.7% reach moderate or high certainty.

Reviews

147

Questions

1,751

current versions

No studies

20.6%

Moderate or high

17.7%

No studies 361 · 20.6%Ungraded 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Pain, Palliative and Supportive Care

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Summary of findings table ‐ Gabapentin vs pregabalin Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	RR 4.7 [0.21, 104.14]	2 studies · 122 participants	Very low
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ GABA‐analogues vs placebo Quality of life ‐ not measured · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	RR 2.54 [0.38, 16.78]	3 studies · 174 participants	Very low
Summary of findings table ‐ Montelukast vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	2 studies · 87 participants	Very low
Summary of findings table ‐ Montelukast vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Montelukast vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 147

Olanzapine for the prevention and treatment of cancer‐related nausea and vomiting in adults

Sutherland, A, Naessens, K, et al. · Cochrane Database of Systematic Reviews · 2018

Pain, Palliative and Supportive Care

Thinnest evidence

Reviews 147

Olanzapine for the prevention and treatment of cancer‐related nausea and vomiting in adults

Mirtazapine for fibromyalgia in adults

Methadone for cancer pain

Single dose oral ketoprofen or dexketoprofen for acute postoperative pain in adults

Topical capsaicin (high concentration) for chronic neuropathic pain in adults

Gabapentin for chronic neuropathic pain in adults

Psychological interventions for acute pain after open heart surgery

Early palliative care for adults with advanced cancer

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain

Morphine for chronic neuropathic pain in adults

Aspirin for acute treatment of episodic tension‐type headache in adults

Transcutaneous electrical nerve stimulation (TENS) for neuropathic pain in adults

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy, radiotherapy, or surgery)

Psychosocial interventions for fatigue during cancer treatment with palliative intent

Interventions for treating persistent pain in survivors of torture

Acupuncture for neuropathic pain in adults

Transcutaneous electrical nerve stimulation (TENS) for fibromyalgia in adults

Gabapentin for fibromyalgia pain in adults

Oral nonsteroidal anti‐inflammatory drugs for fibromyalgia in adults

Methadone for neuropathic pain in adults

Tramadol with or without paracetamol (acetaminophen) for cancer pain

Antidepressants for chronic non‐cancer pain in children and adolescents

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents

Oral paracetamol (acetaminophen) for cancer pain