Cochrane Review Group

Pain, Palliative and Supportive Care

147 systematic reviews in Pain, Palliative and Supportive Care ask 1,751 questions. 20.6% have no studies to answer them, 35.7% rest on very low certainty evidence and 17.7% reach moderate or high certainty.

Reviews

147

Questions

1,751

current versions

No studies

20.6%

Moderate or high

17.7%

No studies 361 · 20.6%Ungraded 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Pain, Palliative and Supportive Care

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Summary of findings table ‐ Gabapentin vs pregabalin Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	RR 4.7 [0.21, 104.14]	2 studies · 122 participants	Very low
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ GABA‐analogues vs placebo Quality of life ‐ not measured · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	RR 2.54 [0.38, 16.78]	3 studies · 174 participants	Very low
Summary of findings table ‐ Montelukast vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	2 studies · 87 participants	Very low
Summary of findings table ‐ Montelukast vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Montelukast vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 147

Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults

Derry, S, Cooper, TE, et al. · Cochrane Database of Systematic Reviews · 2016

Pain, Palliative and Supportive Care

Thinnest evidence

Reviews 147

Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults

Oxycodone for pain in fibromyalgia in adults

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of migraine in adults

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain

Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy

Single dose oral diclofenac for acute postoperative pain in adults

Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache

Interventions for the treatment of metastatic extradural spinal cord compression in adults

Topical NSAIDs for acute musculoskeletal pain in adults

Milnacipran for pain in fibromyalgia in adults

Sweet tasting solutions for reduction of needle‐related procedural pain in children aged one to 16 years

Multidisciplinary rehabilitation after primary brain tumour treatment

Tramadol for postoperative pain treatment in children

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults

Corticosteroids for the management of cancer‐related pain in adults

Ibuprofen for acute treatment of episodic tension‐type headache in adults

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of tension‐type headache in adults

Amitriptyline for fibromyalgia in adults

Single dose oral etoricoxib for acute postoperative pain in adults

Carbamazepine for chronic neuropathic pain and fibromyalgia in adults

Codeine, alone and with paracetamol (acetaminophen), for cancer pain

Salicylate‐containing rubefacients for acute and chronic musculoskeletal pain in adults

Zolmitriptan for acute migraine attacks in adults

Caffeine as an analgesic adjuvant for acute pain in adults