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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,751 questions in 147 reviews · Pain, Palliative and Supportive Care
current versionsNo studies 361 · 20.6%Ungraded 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings table ‐ GABA‐analogues vs placebo Pruritus · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 5 studies · 297 participants | Moderate |
Summary of findings table ‐ Gabapentin vs pregabalin Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 4.7 [0.21, 104.14] | 2 studies · 122 participants | Very low |
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 6 studies · 1292 participants | High |
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Risk for at least one adverse drug reaction (ADR) per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 1.73 [1.2, 2.48] | 5 studies · 1344 participants | Low |
Summary of findings table ‐ Ondansetron vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 4 studies · 202 participants | Low |
Summary of findings table ‐ Ondansetron vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Ondansetron vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Ondansetron vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ GABA‐analogues vs placebo Quality of life ‐ not measured · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Ondansetron vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 2.54 [0.38, 16.78] | 3 studies · 174 participants | Very low |
Summary of findings table ‐ Montelukast vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 87 participants | Very low |
Summary of findings table ‐ Montelukast vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Montelukast vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Montelukast vs placebo depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Montelukast vs placebo Risk for at least one adverse event per participant ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Prurits · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 4 studies · 212 participants | Low |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Quality of life ‐ not measured · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Patient satisfaction ‐ not measured · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Depression ‐ not measured · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ GABA‐analogues vs placebo Patient satisfaction ‐ not measured · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Adverse events ‐ not measured · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Zinc sulphate vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 76 participants | Low |
Summary of findings table ‐ Zinc sulphate vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Zinc sulphate vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Zinc sulphate vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Zinc sulphate vs placebo Risk for at least one adverse event per participant · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 160 participants | Ungraded |
Summary of findings table ‐ Cromolyn sodium vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 100 participants | Very low |
Summary of findings table ‐ Cromolyn sodium vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Cromolyn sodium vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Cromolyn sodium vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ GABA‐analogues vs placebo Depression ‐ not reported · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Cromolyn sodium vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 1.28 [0.02, 106.52] | 2 studies · 122 participants | Very low |
Summary of findings table ‐ Topical capsaicin vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 112 participants | Low |
Summary of findings table ‐ Topical capsaicin vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Topical capsaicin vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Topical capsaicin vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Topical capsaicin vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 3.69 [1.17, 11.67] | 3 studies · 116 participants | Low |
Summary of findings table ‐ Naltrexone vs placebo PruritusScale from: 0 to 10 · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 52 participants | Low |
Summary of findings table ‐ Naltrexone vs placebo Quality of life ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Naltrexone vs placebo Patient satisfaction ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Naltrexone vs placebo Depression ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ GABA‐analogues vs placebo Risk for at least one adverse event per patient · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 2.63 [0.76, 9.05] | 1 study · 15 participants | Low |
Summary of findings table ‐ Naltrexone vs placebo Risk for at least one adverse event per patient · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 2.67 [1.32, 5.39] | 1 study · 40 participants | Low |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Pruritus · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 42 participants | Very low |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Quality of life ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Patient satisfaction ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Depression ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |