Evidence gap map · Oral Health

Dental caries

Rows are interventions or exposures, columns are outcome domains, across Cochrane and non-Cochrane reviews. A cell shows how many reviews address that pair and is colored by the highest certainty available in it, not by an average. Hatched cells are pairs no eligible review addressed, which is not the same as no evidence. Select a cell to see its questions.

ProposalThe intervention and outcome categories are a proposed key pending human validation. Questions that fit no category are left out of the grid and stay searchable.

HighModerateLowVery lowUngraded (effects reported, none GRADE rated)Only questions with no studiesNo review identified

210 filled cells · 36 interventions × 17 outcome domains · 562 review cell entries
Intervention or exposure	Adverse effects/fluorosis	Caries increment (DMFS/DMFT)	Caries (unspecified)	Diagnostic accuracy	Lesion arrest/remineralization	Microbiological/plaque	Periodontal/gingival	Restoration survival/failure	Quality of life	Behavioral/uptake	Cost/economic	Caries incidence/onset	Secondary caries	White-spot/initial lesions	Caries prevalence	Root caries	Association/risk factor
Oral hygiene/education	921 questions	631 questions	716 questions	no review identified	no review identified	45 questions	1042 questions	22 questions	814 questions	614 questions	22 questions	no review identified	no review identified	no review identified	no review identified	11 questions	no review identified
Fluoride mouthrinse	1629 questions	13 questions	no review identified	22 questions	16 questions	617 questions	321 questions	11 questions	33 questions	22 questions	22 questions	11 questions	no review identified	no review identified	11 questions	no review identified	no review identified
Glass ionomer / ART	57 questions	212 questions	13 questions	515 questions	11 questions	11 questions	25 questions	871 questions	26 questions	no review identified	24 questions	no review identified	720 questions	35 questions	no review identified	no review identified	no review identified
Fluoride toothpaste/dentifrice	831 questions	878 questions	11 questions	15 questions	14 questions	39 questions	35 questions	no review identified	11 questions	35 questions	no review identified	310 questions	no review identified	22 questions	no review identified	11 questions	12 questions
Laser/photodynamic	1015 questions	no review identified	12 questions	591 questions	36 questions	12 questions	413 questions	316 questions	46 questions	11 questions	no review identified	no review identified	no review identified	12 questions	no review identified	no review identified	no review identified
Fluoride varnish	69 questions	945 questions	no review identified	no review identified	537 questions	33 questions	no review identified	no review identified	12 questions	36 questions	11 questions	410 questions	no review identified	12 questions	no review identified	no review identified	no review identified
Caries detection/diagnosis	no review identified	11 questions	no review identified	21555 questions	no review identified	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	334 questions	11 questions	no review identified
Diet/sugar	413 questions	519 questions	827 questions	no review identified	no review identified	34 questions	12 questions	no review identified	12 questions	22 questions	11 questions	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified
Operative/pulp treatment	37 questions	no review identified	no review identified	24 questions	217 questions	no review identified	44 questions	715 questions	44 questions	no review identified	34 questions	no review identified	12 questions	no review identified	no review identified	no review identified	no review identified
Restorative materials	55 questions	no review identified	no review identified	22 questions	24 questions	no review identified	no review identified	753 questions	no review identified	no review identified	33 questions	no review identified	719 questions	no review identified	no review identified	no review identified	no review identified
Pit-and-fissure sealants	612 questions	35 questions	13 questions	no review identified	615 questions	no review identified	no review identified	423 questions	no review identified	no review identified	11 questions	28 questions	no review identified	18 questions	112 questions	14 questions	no review identified
Silver diamine fluoride (SDF)	313 questions	no review identified	11 questions	110 questions	1192 questions	no review identified	no review identified	11 questions	14 questions	no review identified	no review identified	22 questions	14 questions	no review identified	no review identified	no review identified	no review identified
Exposure/condition: systemic-oral	no review identified	45 questions	320 questions	no review identified	no review identified	34 questions	26 questions	no review identified	12 questions	no review identified	no review identified	no review identified	no review identified	no review identified	11 questions	22 questions	no review identified
Chlorhexidine	58 questions	14 questions	11 questions	110 questions	no review identified	22 questions	11 questions	22 questions	no review identified	no review identified	11 questions	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified
Exposure: maternal/perinatal	no review identified	22 questions	868 questions	no review identified	no review identified	no review identified	no review identified	no review identified	22 questions	no review identified	no review identified	no review identified	no review identified	no review identified	13 questions	no review identified	no review identified
Nutritional supplement	33 questions	24 questions	319 questions	11 questions	12 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	11 questions	no review identified	11 questions	12 questions	no review identified	no review identified
Exposure: socioeconomic	no review identified	413 questions	36 questions	no review identified	no review identified	11 questions	no review identified	no review identified	39 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Fluoride gel/foam	34 questions	313 questions	no review identified	no review identified	110 questions	no review identified	no review identified	no review identified	no review identified	24 questions	no review identified	11 questions	no review identified	no review identified	12 questions	no review identified	no review identified
Antimicrobial (other)	34 questions	no review identified	no review identified	no review identified	no review identified	33 questions	23 questions	no review identified	no review identified	no review identified	11 questions	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified
Xylitol/polyols	15 questions	212 questions	no review identified	no review identified	no review identified	514 questions	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Exposure: genetic	no review identified	12 questions	6371 questions	no review identified	no review identified	no review identified	12 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Herbal/natural product	510 questions	no review identified	no review identified	no review identified	no review identified	17 questions	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Exposure: microbial	13 questions	11 questions	116 questions	25 questions	no review identified	24 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Exposure: smoking/tobacco	no review identified	no review identified	12 questions	no review identified	no review identified	25 questions	13 questions	no review identified	no review identified	no review identified	no review identified	11 questions	no review identified	11 questions	12 questions	no review identified	no review identified
Casein / CPP-ACP	no review identified	no review identified	no review identified	no review identified	59 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified
Probiotics	no review identified	no review identified	23 questions	no review identified	no review identified	212 questions	12 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified
Resin infiltration	no review identified	no review identified	no review identified	no review identified	425 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	12 questions	no review identified	no review identified	no review identified
Fluoride supplements	25 questions	211 questions	no review identified	no review identified	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Slow-release fluoride device	11 questions	12 questions	no review identified	no review identified	11 questions	no review identified	no review identified	11 questions	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Systemic/community fluoridation	13 questions	15 questions	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	12 questions	no review identified	no review identified	no review identified	13 questions	no review identified	no review identified
Exposure: obesity/BMI	no review identified	223 questions	222 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Caries risk assessment	no review identified	195 questions	no review identified	2114 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Nano-hydroxyapatite	11 questions	no review identified	no review identified	no review identified	11 questions	no review identified	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
School/community program	no review identified	no review identified	11 questions	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Ozone therapy	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified
Exposure: infant feeding/diet	no review identified	no review identified	11 questions	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified	no review identified

A review spanning several cells counts in each. Each cell's tooltip also gives the primary studies its non-Cochrane reviews include; that count covers all of those reviews' outcomes, not only this cell, and some matches are probable. Cell data is also in the API.