Cochrane Review Group

Pain, Palliative and Supportive Care

147 systematic reviews in Pain, Palliative and Supportive Care ask 1,751 questions. 20.6% have no studies to answer them, 35.7% rest on very low certainty evidence and 17.7% reach moderate or high certainty.

Reviews

147

Questions

1,751

current versions

No studies

20.6%

Moderate or high

17.7%

No studies 361 · 20.6%Ungraded 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Pain, Palliative and Supportive Care

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Summary of findings table ‐ Gabapentin vs pregabalin Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	RR 4.7 [0.21, 104.14]	2 studies · 122 participants	Very low
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ GABA‐analogues vs placebo Quality of life ‐ not measured · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	RR 2.54 [0.38, 16.78]	3 studies · 174 participants	Very low
Summary of findings table ‐ Montelukast vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	2 studies · 87 participants	Very low
Summary of findings table ‐ Montelukast vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Montelukast vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 147

Nalbuphine for postoperative pain treatment in children

Schnabel, A, Reichl, SU, et al. · Cochrane Database of Systematic Reviews · 2014

Pain, Palliative and Supportive Care

Thinnest evidence

Reviews 147

Nalbuphine for postoperative pain treatment in children

Imipramine for neuropathic pain in adults

Levetiracetam for neuropathic pain in adults

Topical lidocaine for neuropathic pain in adults

Desipramine for neuropathic pain in adults

Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome

Megestrol acetate for treatment of anorexia‐cachexia syndrome

Opioids for the management of breakthrough pain in cancer patients

Lamotrigine for chronic neuropathic pain and fibromyalgia in adults

Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults

Ibuprofen with or without an antiemetic for acute migraine headaches in adults

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults

Aspirin with or without an antiemetic for acute migraine headaches in adults

Triptans for acute cluster headache

Diclofenac with or without an antiemetic for acute migraine headaches in adults

Naproxen with or without an antiemetic for acute migraine headaches in adults

Cognitive behavioural therapies for fibromyalgia

Anticonvulsants for fibromyalgia

Radioisotopes for metastatic bone pain

Laxatives or methylnaltrexone for the management of constipation in palliative care patients

Drug therapy for the management of cancer‐related fatigue

Calcitonin for metastatic bone pain