Cochrane · systematic review · CD003347
Radioisotopes for metastatic bone pain
Roqué i Figuls Marta, Martinez-Zapata Maria José, Scott-Brown Martin, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Radioisotopes compared to Placebo for metastatic bone pain
Population: patients with metastatic bone pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain relief ‐ Complete relief Radioisotopes vs Placebo | RR 2.1 [1.32, 3.35] | 4 studies · 296 participants | Moderate Downgraded: risk of bias |
Pain relief ‐ Complete/Partial relief Radioisotopes vs Placebo | RR 1.72 [1.13, 2.63] | 3 studies · 119 participants | Moderate |
Compression of spinal cord Radioisotopes vs Placebo | RR 1.1 [0.39, 3.07] | 2 studies · 270 participants | Low Downgraded: risk of bias |
Pain flares Radioisotopes vs Placebo | RR 0.74 [0.27, 2.06] | 2 studies · 270 participants | Low Downgraded: risk of bias |
Thrombocytopenia III‐IV Radioisotopes vs Placebo | RR 2.21 [0.98, 4.99] | 4 studies · 313 participants | Low Downgraded: risk of bias |
Leucocytopenia III‐IV Radioisotopes vs Placebo | RR 5.9 [1.62, 21.47] | 4 studies · 410 participants | Low Downgraded: risk of bias |