Cochrane · systematic review · CD003448
Laxatives or methylnaltrexone for the management of constipation in palliative care patients
Candy Bridget, Jones Louise, Goodman Margaret Lynn, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
2
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Methylnaltrexone compared to placebo for the management of constipation in palliative care patients
Population: patients with the management of opioid‐induced constipation in palliative care patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Rescue free laxation within 4 hours Methylnaltrexone vs placebo | OR 6.95 [3.83, 12.61] | 2 studies · 287 participants | Moderate Downgraded: risk of bias, publication bias |
Rescue free laxation within 24 hours Methylnaltrexone vs placebo | OR 5.42 [3.12, 9.41] | 2 studies · 287 participants | Moderate Downgraded: risk of bias, publication bias |