Cochrane · systematic review · CD010769
Imipramine for neuropathic pain in adults
Hearn, L, Derry, S, Phillips, T, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 4 · 57.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: neuropathic pain (5 studies in painful diabetic neuropathy and polyneuropathy)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
At least 50% reduction in pain or equivalent | no estimate extracted | NR | No studies |
"Moderate" benefit At least 30% reduction in pain | no estimate extracted | NR | No studies |
Proportion below 30/100 mm on VAS | no estimate extracted | NR | No studies |
Patient Global Impression of Change much or very much improved | no estimate extracted | 1 study · 40 participants | Very low |
Adverse event withdrawals | no estimate extracted | 4 studies · 109 participants | Very low |
Serious adverse events | no estimate extracted | 5 studies · 168 participants | Very low |
Death | no estimate extracted | 5 studies · 168 participants | Very low |