evidence/gaps
Cochrane · systematic review · CD010943

Levetiracetam for neuropathic pain in adults

Wiffen, PJ, Derry, S, Moore, RA, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library

Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
8
No studies
1
Included studies
NR
No studies 1 · 11.1%Ungraded 0 · 0%Very low 8 · 88.9%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Comparison

Population: neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke pain, postherpetic neuralgia, and post‐mastectomy pain)
9 questions
OutcomeEffectEvidenceStatus / GRADE
At least 50% reduction in pain
no estimate extracted2 studies · 59 participantsVery low
At least 30% reduction in pain
no estimate extracted2 studies · 59 participantsVery low
Proportion below 30/100 mm on VAS
no estimate extractedNRNo studies
Patient Global Impression of Change very much improved (patient global evaluation of pain relief complete or good)
no estimate extracted3 studies · 86 participantsVery low
Patient Global Impression of Change much or very much improved (patient global evaluation of pain relief complete, good or moderate)
no estimate extracted3 studies · 86 participantsVery low
Any measure of 'substantial' pain relief
no estimate extracted4 studies · 121 participantsVery low
Adverse event withdrawals
RR 4.9 [2.2, 11]6 studies · 334 participantsVery low
Serious adverse events
no estimate extracted6 studies · 334 participantsVery low
Death
no estimate extractedNRVery low