Cochrane · systematic review · CD004310
Megestrol acetate for treatment of anorexia‐cachexia syndrome
Ruiz Garcia, V, López‐Briz, E, Carbonell Sanchis, R, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 85.7%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Megestrol acetate for cachexia anorexia syndrome
Population: cachexia anorexia syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Appetite improvement compared with placebo Subjective sense of appetite, responses to | RR 2.19 [1.41, 3.4] | 5 studies · 699 participants | Very low Downgraded: risk of bias, inconsistency |
Weight improvement compared with placebo % of patients that improved their weight in kg | RR 1.51 [1.08, 2.11] | 10 studies · 1106 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Appetite improvement compared to other drugs Questionnaire of appetite rating | RR 1.03 [0.64, 1.67] | 1 study · 475 participants | Low Downgraded: risk of bias |
Weight improvement compared to other drugs % of patients that improved their weight in kg | RR 1.66 [1.09, 2.52] | 7 studies · 1131 participants | Very low Downgraded: risk of bias, inconsistency |
Deaths | RR 1.42 [1.04, 1.94] | 10 studies · 1307 participants | Very low Downgraded: risk of bias, imprecision |
Thromboembolic phenomena including thrombophlebitis | RR 1.84 [1.07, 3.18] | 11 studies · 1544 participants | Very low Downgraded: risk of bias |
Oedema | RR 1.36 [1.07, 1.72] | 12 studies · 2182 participants | Very low Downgraded: risk of bias |