Cochrane Review Group

Pain, Palliative and Supportive Care

147 systematic reviews in Pain, Palliative and Supportive Care ask 1,751 questions. 20.6% have no studies to answer them, 35.7% rest on very low certainty evidence and 17.7% reach moderate or high certainty.

Reviews

147

Questions

1,751

current versions

No studies

20.6%

Moderate or high

17.7%

No studies 361 · 20.6%Ungraded 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Pain, Palliative and Supportive Care

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Summary of findings table ‐ Gabapentin vs pregabalin Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	RR 4.7 [0.21, 104.14]	2 studies · 122 participants	Very low
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ GABA‐analogues vs placebo Quality of life ‐ not measured · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Ondansetron vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	RR 2.54 [0.38, 16.78]	3 studies · 174 participants	Very low
Summary of findings table ‐ Montelukast vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	2 studies · 87 participants	Very low
Summary of findings table ‐ Montelukast vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Montelukast vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 147

Oral nonsteroidal anti‐inflammatory drugs (NSAIDs) for cancer pain in adults

Derry, S, Wiffen, PJ, et al. · Cochrane Database of Systematic Reviews · 2017

Pain, Palliative and Supportive Care

Thinnest evidence

Reviews 147

Oral nonsteroidal anti‐inflammatory drugs (NSAIDs) for cancer pain in adults

Acupuncture for the prevention of episodic migraine

Local anaesthetic sympathetic blockade for complex regional pain syndrome

Drugs for the acute treatment of migraine in children and adolescents

Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain

Topical NSAIDs for chronic musculoskeletal pain in adults

Educational interventions for the management of cancer‐related fatigue in adults

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults

Single dose intra‐articular morphine for pain control after knee arthroscopy

Posture and fluids for preventing post‐dural puncture headache

Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease

Massage with or without aromatherapy for symptom relief in people with cancer

Oxycodone for neuropathic pain in adults

Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness

Infraorbital nerve block for postoperative pain following cleft lip repair in children

Breastfeeding for procedural pain in infants beyond the neonatal period

Single dose dipyrone (metamizole) for acute postoperative pain in adults

Liposomal bupivacaine peripheral nerve block for the management of postoperative pain

Hydromorphone for neuropathic pain in adults

Fentanyl for neuropathic pain in adults

Pregabalin for pain in fibromyalgia in adults

Antipsychotics for fibromyalgia in adults

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults

Ketoprofen for episodic tension‐type headache in adults

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults