Cochrane · systematic review · CD007400
Topical NSAIDs for chronic musculoskeletal pain in adults
Derry, S, Conaghan, P, Da Silva, JAP, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 1 · 16.7%Moderate 4 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: adults with chronic musculoskeletal pain (osteoarthritis)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Topical diclofenac gel or solution Clinical success (for example 50% reduction in pain) | no estimate extracted | 6 studies · 2342 participants | Moderate |
Topical ketoprofen gel Clinical success (for example 50% reduction in pain) | no estimate extracted | 4 studies · 2573 participants | Moderate |
Topical diclofenac gel or solution Local adverse events | no estimate extracted | 15 studies · 3658 participants | Moderate |
Topical ketoprofen gel Local adverse events | no estimate extracted | 4 studies · 2621 participants | Moderate |
Systemic adverse events | no estimate extracted | NR | Low |
Serious adverse events | no estimate extracted | 30 participants | Very low |