Cochrane · systematic review · CD008918
Single dose intra‐articular morphine for pain control after knee arthroscopy
Zou, Z, An, MM, Xie, Q, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
30
current version
GRADE rated
26
No studies
4
Included studies
NR
No studies 4 · 13.3%Ungraded 0 · 0%Very low 2 · 6.7%Low 19 · 63.3%Moderate 5 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Morphine compared with placebo for pain control after knee arthroscopy
Population: patients undergoing knee arthroscopy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs placebo | no estimate extracted | 7 studies · 297 participants | Low Downgraded: risk of bias |
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs placebo | no estimate extracted | 7 studies · 297 participants | Low Downgraded: risk of bias |
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs placebo | no estimate extracted | 7 studies · 297 participants | Low Downgraded: risk of bias |
Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. Morphine vs placebo | no estimate extracted | 3 studies · 124 participants | Low Downgraded: risk of bias, publication bias |
Adverse eventsPercentage of participants with any adverse event Morphine vs placebo | RR 1.09 [0.51, 2.36] | 8 studies · 314 participants | Low Downgraded: risk of bias, publication bias |
Morphine compared with bupivacaine for pain control after knee arthroscopy
Population: patients undergoing knee arthroscopy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs bupivacaine | no estimate extracted | 5 studies · 248 participants | Low Downgraded: risk of bias |
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs bupivacaine | no estimate extracted | 6 studies · 330 participants | Low Downgraded: risk of bias |
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs bupivacaine | no estimate extracted | 5 studies · 270 participants | Low Downgraded: risk of bias |
Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. Morphine vs bupivacaine | no estimate extracted | 3 studies · 162 participants | Moderate Downgraded: risk of bias, publication bias |
Adverse eventsPercentage of participants with any adverse event Morphine vs bupivacaine | RR 0.68 [0.09, 5.17] | 4 studies · 210 participants | Moderate Downgraded: risk of bias, publication bias |
Morphine compared with NSAIDs for pain control after knee arthroscopy
Population: patients undergoing knee arthroscopy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs NSAIDs | no estimate extracted | 2 studies · 80 participants | Very low Downgraded: risk of bias |
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs NSAIDs | no estimate extracted | 2 studies · 80 participants | Low Downgraded: risk of bias |
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. Morphine vs NSAIDs | no estimate extracted | 2 studies · 80 participants | Low Downgraded: risk of bias |
Analgesia durationtime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. Morphine vs NSAIDs | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Adverse eventsPercentage of participants with any adverse event Morphine vs NSAIDs | RR 0.75 [0.19, 3.04] | 3 studies · 120 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Different doses of morphine for pain control after knee arthroscopy
Population: patients undergoing knee arthroscopy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity VAS score 1 mg morphine vs 2 mg morphine0‐10 cm VAS score. Scale from: 0 to 10. | no estimate extracted | 2 studies · 105 participants | Low Downgraded: publication bias |
Pain intensity VAS score1 mg morphine vs 2 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. | no estimate extracted | 2 studies · 105 participants | Low Downgraded: publication bias |
Pain intensity VAS score1 mg morphine vs 2 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. | no estimate extracted | 1 study · 45 participants | Low Downgraded: publication bias |
Analgesia duration 1 mg morphine vs 2 mg morphineTime duration from the end of surgery to the time of first analgesic consumption | no estimate extracted | 1 study · 60 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Adverse events 1 mg morphine vs 2 mg morphinePercentage of participants with any adverse event | no estimate extracted | NR | No studies |
Pain intensity VAS score1 mg morphine vs 4 mg/5 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. | no estimate extracted | 2 studies · 67 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Pain intensity VAS score1 mg morphine vs 4 mg/5 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. | no estimate extracted | 2 studies · 67 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Pain intensity VAS score1 mg morphine vs 4 mg/5 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. | no estimate extracted | 2 studies · 67 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Analgesia duration 1 mg morphine vs 4 mg/5 mg morphinetime duration from the end of surgery to the first time of analgesic consumption | no estimate extracted | 1 study · 24 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Adverse events 1 mg morphine vs 4 mg/5 mg morphinePercentage of participants with any adverse event | no estimate extracted | NR | No studies |
IA morphine compared with IM morphine for pain control after knee arthroscopy
Population: patients undergoing knee arthroscopy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. IA morphine vs IM morphine | no estimate extracted | 2 studies · 72 participants | Very low Downgraded: risk of bias |
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. IA morphine vs IM morphine | no estimate extracted | 2 studies · 72 participants | Low Downgraded: risk of bias |
Pain intensity VAS score0‐10 cm VAS score. Scale from: 0 to 10. IA morphine vs IM morphine | no estimate extracted | 1 study · 39 participants | Low Downgraded: risk of bias |
Analgesia durationtime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. IA morphine vs IM morphine | no estimate extracted | NR | No studies |
Adverse eventsPercentage of participants with any adverse event IA morphine vs IM morphine | no estimate extracted | NR | No studies |