Cochrane · systematic review · CD011476
Liposomal bupivacaine peripheral nerve block for the management of postoperative pain
Hamilton, TW, Athanassoglou, V, Trivella, M, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
3
No studies
6
Included studies
NR
No studies 6 · 66.7%Ungraded 0 · 0%Very low 3 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain
Population: adults aged ≥ 18 years undergoing elective surgery at any surgical site
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cumulative pain score from the end of operation (0 hours) to 72 hours | no estimate extracted | NR | No studies |
Serious adverse events | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mean pain score at 12, 24, 48, 72, and 96 hours following surgery | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Time to first postoperative opioid dose | no estimate extracted | NR | No studies |
Total postoperative opioid consumption over first 72 hours | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Percentage of participants not requiring postoperative opioids over initial 72 hours | no estimate extracted | NR | No studies |
Health economic assessment | no estimate extracted | NR | No studies |
Incidence of adverse events within 30 days of surgery | no estimate extracted | NR | No studies |
Patient‐reported outcomes | no estimate extracted | NR | No studies |