Cochrane · systematic review · CD012227
Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults
Wiffen, PJ, Knaggs, R, Derry, S, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine compared with placebo for neuropathic pain
Population: adults with chronic neuropathic pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo | no estimate extracted | NR | Very low |
Substantial benefit: At least 50% reduction in pain, or PGIC much improved Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo | no estimate extracted | NR | Very low |
Lack of efficacy withdrawal Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo | no estimate extracted | NR | Very low |
Adverse event withdrawal Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo | no estimate extracted | NR | Very low |
Serious adverse events Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo | no estimate extracted | NR | Very low |
Deaths Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo | no estimate extracted | NR | Very low |