Cochrane · systematic review · CD005220
Drugs for the acute treatment of migraine in children and adolescents
Richer, L, Billinghurst, L, Linsdell, MA, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 25%Very low 0 · 0%Low 0 · 0%Moderate 6 · 75%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Should ibuprofen be used to treat children with migraine?
Population: acute treatment of migraine in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain freedom at 2 h | RR 1.87 [1.15, 3.04] | 2 studies · 125 participants | Ungraded |
Adverse events | RD 0 | 1 study · 80 participants | Ungraded |
Should triptans be used to treat children with migraine?
Population: acute treatment of migraine in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain freedom at 2 h | RR 1.67 [1.06, 2.62] | 3 studies · 345 participants | Moderate Downgraded: imprecision, inconsistency, indirectness, publication bias |
Adverse events | RD 0.06 | 3 studies · 420 participants | Moderate Downgraded: imprecision, inconsistency, indirectness, publication bias |
Should triptans be used to treat adolescents with migraine?
Population: acute treatment of migraine in adolescents
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain freedom at 2 h | RR 1.32 [1.19, 1.47] | 21 studies · 6761 participants | Moderate Downgraded: imprecision, inconsistency |
Adverse events | RD 0.13 [0.08, 0.18] | 21 studies · 7876 participants | Moderate Downgraded: imprecision, inconsistency |
Should sumatriptan plus naproxen sodium be used to treat adolescents with migraine?
Population: acute treatment of migraine in adolescents
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain freedom at 2 h | RR 2.66 [1.57, 4.51] | 1 study · 485 participants | Moderate |
Adverse events | RD 0.03 | 1 study · 490 participants | Moderate |