Cochrane · systematic review · CD011889
Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults
Stephens, G, Derry, S, Moore, RA · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
11
No studies
3
Included studies
NR
No studies 3 · 21.4%Ungraded 0 · 0%Very low 1 · 7.1%Low 3 · 21.4%Moderate 4 · 28.6%High 3 · 21.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Paracetamol 1000 mg compared with placebo for episodic tension‐type headache
Population: adults with episodic tension‐type headache
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain‐free at 2 hours Paracetamol 1000 mg vs placebo | no estimate extracted | NR | High |
Pain‐free at 1 hour Paracetamol 1000 mg vs placebo | no estimate extracted | NR | Moderate |
Pain‐free at 4 hours Paracetamol 1000 mg vs placebo | no estimate extracted | NR | Moderate |
Use of rescue medication Paracetamol 1000 mg vs placebo | no estimate extracted | NR | Moderate |
Pain‐free or mild pain at 2 hours Paracetamol 1000 mg vs placebo | no estimate extracted | NR | High |
Any adverse event Paracetamol 1000 mg vs placebo | no estimate extracted | NR | High |
Serious adverse events Paracetamol 1000 mg vs placebo | no estimate extracted | NR | Moderate |
Paracetamol 500 mg to 650 mg compared with placebo for episodic tension‐type headache
Population: adults with episodic tension‐type headache
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain‐free at 2 hours Paracetamol 500 mg to 650 mg vs placebo | no estimate extracted | NR | No studies |
Pain‐free at 1 hour Paracetamol 500 mg to 650 mg vs placebo | no estimate extracted | NR | No studies |
Pain‐free at 4 hours Paracetamol 500 mg to 650 mg vs placebo | no estimate extracted | NR | No studies |
Use of rescue medication Paracetamol 500 mg to 650 mg vs placebo | no estimate extracted | NR | Low |
Pain‐free or mild pain at 2 hours Paracetamol 500 mg to 650 mg vs placebo | no estimate extracted | NR | Low |
Any adverse event Paracetamol 500 mg to 650 mg vs placebo | no estimate extracted | NR | Low |
Serious adverse events Paracetamol 500 mg to 650 mg vs placebo | no estimate extracted | NR | Very low |