Cochrane · systematic review · CD008541

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults

Law, S, Derry, S, Moore, RA · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

Pain, Palliative and Supportive Care2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 1 · 11.1%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 33.3%High 5 · 55.6%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Sumatriptan 50 mg or 85 mg plus naproxen 500 mg compared with placebo for migraine headache

Population: adults with migraine headache ‐ moderate or severe and mild baseline pain

9 questions

Outcome	Effect	Evidence	Status / GRADE
Pain‐free response at 2 h for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	High
Pain‐free response at 2 h for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	High
Headache relief at 2 h for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	High
Sustained pain‐free during the 24 h post dose for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	Moderate
Sustained pain‐free during the 24 h post dose for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	High
Sustained headache relief during the 24 h post dose for moderate or severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	High
At least 1 AE during treatment for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	Moderate
At least 1 AE during treatment for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	Moderate
Serious AE (all levels of baseline pain) Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo	no estimate extracted	NR	No studies