Cochrane · systematic review · CD008541
Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults
Law, S, Derry, S, Moore, RA · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
8
No studies
1
Included studies
NR
No studies 1 · 11.1%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 33.3%High 5 · 55.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySumatriptan 50 mg or 85 mg plus naproxen 500 mg compared with placebo for migraine headache
Population: adults with migraine headache ‐ moderate or severe and mild baseline pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain‐free response at 2 h for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
Pain‐free response at 2 h for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
Headache relief at 2 h for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
Sustained pain‐free during the 24 h post dose for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | Moderate |
Sustained pain‐free during the 24 h post dose for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
Sustained headache relief during the 24 h post dose for moderate or severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
At least 1 AE during treatment for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | Moderate |
At least 1 AE during treatment for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | Moderate |
Serious AE (all levels of baseline pain) Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | No studies |
Sumatriptan 50 mg or 85 mg plus naproxen 500 mg compared with placebo for migraine headache
Population: adults with migraine headache ‐ moderate or severe and mild baseline pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain‐free response at 2 h for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
Pain‐free response at 2 h for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
Headache relief at 2 h for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
Sustained pain‐free during the 24 h post dose for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | Moderate Downgraded: publication bias |
Sustained pain‐free during the 24 h post dose for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
Sustained headache relief during the 24 h post dose for moderate or severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | High |
At least 1 AE during treatment for moderate to severe baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | Moderate Downgraded: publication bias |
At least 1 AE during treatment for mild baseline pain Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | Moderate Downgraded: publication bias |
Serious AE (all levels of baseline pain) Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo | no estimate extracted | NR | No studies |