Cochrane · systematic review · CD010782
Anticonvulsants for fibromyalgia
Üçeyler Nurcan, Sommer Claudia, Walitt Brian, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 14.3%High 6 · 85.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Pregabalin versus placebo at end of treatment for fibromyalgia
Population: People with fibromyalgia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
50% pain reduction Pregabalin vs placebo at end of treatment | RR 1.59 [1.33, 1.9] | 5 studies · 3256 participants | High |
Patient Global Impression of Change of 'much' or 'very much' improved Pregabalin vs placebo at end of treatment | RR 1.38 [1.23, 1.55] | 5 studies · 3183 participants | High |
Fatigue (1‐50 scale) Higher scores indicate higher fatigue levels Pregabalin vs placebo at end of treatment | no estimate extracted | 5 studies · 3195 participants | High |
Sleep problems (0‐100 scale). Higher scores indicate more sleep problems Pregabalin vs placebo at end of treatment | no estimate extracted | 5 studies · 3139 participants | High |
Withdrawal due to adverse events Pregabalin vs placebo at end of treatment | RR 1.68 [1.36, 2.07] | 5 studies · 3259 participants | High |
Serious adverse events Pregabalin vs placebo at end of treatment | RR 1.03 [0.71, 1.49] | 4 studies · 2729 participants | Moderate Downgraded: imprecision |
Dizziness reported to be an adverse event Pregabalin vs placebo at end of treatment | RR 3.77 [3.06, 4.63] | 5 studies · 3257 participants | High |