Cochrane · systematic review · CD009574
Tramadol for postoperative pain treatment in children
Schnabel, A, Reichl, SU, Meyer‐Frießem, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
14
No studies
2
Included studies
NR
No studies 2 · 12.5%Ungraded 0 · 0%Very low 6 · 37.5%Low 6 · 37.5%Moderate 2 · 12.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tramadol compared with placebo
Population: children undergoing surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients requiring rescue analgesia (PACU) Tramadol vs placebo | RR 0.4 [0.2, 0.78] | 5 studies · 289 participants | Low |
Number of patients with moderate to severe pain (PACU) Tramadol vs placebo | no estimate extracted | 1 study · 44 participants | Very low |
Number of patients with PONV (PACU) Tramadol vs placebo | RR 0.84 [0.28, 2.52] | 3 studies · 215 participants | Moderate |
Number of patients with PONV (24 hours postoperatively) Tramadol vs placebo | RR 0.78 [0.54, 1.12] | 4 studies · 150 participants | Moderate |
Tramadol compared with morphine
Population: children undergoing surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients requiring rescue analgesia (PACU) Tramadol vs morphine | RR 1.25 [0.83, 1.89] | 3 studies · 127 participants | Low |
Number of patients with moderate to severe pain (PACU) Tramadol vs morphine | no estimate extracted | NR | No studies |
Number of patients requiring rescue analgesia (24 hours postoperatively) Tramadol vs morphine | RR 1.62 [0.65, 4.04] | 3 studies · 151 participants | Low |
Tramadol compared with nalbuphine
Population: children undergoing surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients requiring rescue analgesia (24 hours postoperatively) Tramadol vs nalbuphine | RR 0.63 [0.16, 2.45] | 2 studies · 110 participants | Very low |
Number of patients with moderate to severe pain (PACU) Tramadol vs nalbuphine | no estimate extracted | 1 study · 50 participants | Very low |
Number of patients with PONV (PACU) Tramadol vs nalbuphine | RR 1 [0.5, 2.01] | 2 studies · 137 participants | Low |
Tramadol compared with pethidine
Population: children undergoing surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients requiring rescue analgesia (PACU) Tramadol vs pethidine | RR 0.93 [0.43, 2.02] | 2 studies · 120 participants | Very low |
Number of patients with moderate to severe pain (PACU) Tramadol vs pethidine | RR 0.64 [0.36, 1.16] | 2 studies · 94 participants | Low |
Number of patients with PONV (PACU) Tramadol vs pethidine | RR 0.75 [0.28, 2.02] | 3 studies · 156 participants | Low |
Tramadol compared with fentanyl
Population: children undergoing surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients requiring rescue analgesia (24 hours postoperatively) Tramadol vs fentanyl | no estimate extracted | 1 study · 28 participants | Very low |
Number of patients with moderate to severe pain (PACU) Tramadol vs fentanyl | no estimate extracted | NR | No studies |
Number of patients with PONV (24 hours postoperatively) Tramadol vs fentanyl | no estimate extracted | 1 study · 28 participants | Very low |