Cochrane · systematic review · CD011681
Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of tension‐type headache in adults
Banzi, R, Cusi, C, Randazzo, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
13
No studies
1
Included studies
NR
No studies 1 · 7.1%Ungraded 0 · 0%Very low 5 · 35.7%Low 8 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
SSRIs or SNRIs versus placebo for tension‐type headache
Population: patients with tension‐type headache
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Headache frequency (number of days with headache) SSRIs or SNRIs vs placebo | no estimate extracted | 2 studies · 127 participants | Low Downgraded: risk of bias, imprecision |
Headache intensity (score) SSRIs or SNRIs vs placebo | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
Headache duration (hours) SSRIs or SNRIs vs placebo | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
Symptomatic/analgesic medication for acute headache attacks (doses/month) SSRIs or SNRIs vs placebo | no estimate extracted | 2 studies · 118 participants | Low Downgraded: risk of bias, imprecision |
Headache index SSRIs or SNRIs vs placebo | no estimate extracted | 2 studies · 128 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life SSRIs or SNRIs vs placebo | no estimate extracted | NR | No studies |
Withdrawals due to adverse events SSRIs or SNRIs vs placebo | OR 3.72 [0.79, 17.53] | 3 studies · 190 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
SSRIs or SNRIs versus other antidepressants for tension‐type headache
Population: patients with tension‐type headache
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Headache frequency (number of days with headache) SSRIs or SNRIs vs other antidepressants | no estimate extracted | 2 studies · 152 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Headache intensity (mean score) SSRIs or SNRIs vs other antidepressants | no estimate extracted | 2 studies · 152 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Headache duration (hours) SSRIs or SNRIs vs other antidepressants | no estimate extracted | 2 studies · 152 participants | Low Downgraded: risk of bias, imprecision |
Symptomatic/analgesic medication for acute headache attacks (doses/4 weeks) SSRIs or SNRIs vs other antidepressants | no estimate extracted | 2 studies · 152 participants | Low Downgraded: risk of bias, imprecision |
Headache index SSRIs or SNRIs vs other antidepressants | no estimate extracted | 2 studies · 152 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life SSRIs or SNRIs vs other antidepressants | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision |
Withdrawals due to adverse events SSRIs or SNRIs vs other antidepressants | OR 1.04 [0.41, 2.6] | 4 studies · 257 participants | Low Downgraded: risk of bias, imprecision |