Cochrane · systematic review · CD011509
Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults
Derry, S, Wiffen, PJ, Moore, RA · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Adults with acute pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
At least 50% of maximum pain relief over 4 to 6 h | RR 5.5 [3.5, 8.7] | 4 studies · 334 participants | Moderate |
Participants remedicating within 8 hours | RR 0.5 [0.4, 0.6] | 3 studies · 293 participants | Moderate |
Participants with at least 1 adverse event | RR 1.9 [0.91, 3.8] | 4 studies · 336 participants | Low |
Participants with a serious adverse event | no estimate extracted | 4 studies · 336 participants | Low |