Cochrane · systematic review · CD011824
Amitriptyline for fibromyalgia in adults
Moore, RA, Derry, S, Aldington, D, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
2
No studies
3
Included studies
NR
No studies 3 · 60%Ungraded 0 · 0%Very low 2 · 40%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: adults with fibromyalgia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
At least 50% reduction in pain or equivalent (substantial) | RR 2.9 [1.7, 4.9] | 4 studies · 275 participants | Very low |
At least 30% reduction in pain or equivalent (moderate) | no estimate extracted | NR | No studies |
Adverse event withdrawals | RR 1.03 [0.49, 2.2] | 4 studies · 298 participants | Very low |
Serious adverse events | no estimate extracted | NR | No studies |
Death | no estimate extracted | NR | No studies |