Cochrane · systematic review · CD002919
Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of migraine in adults
Banzi, R, Cusi, C, Randazzo, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
3
Included studies
NR
No studies 3 · 21.4%Ungraded 1 · 7.1%Very low 4 · 28.6%Low 6 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
SSRIs or SNRIs compared to placebo for migraine prevention in adults
Population: patients for whom migraine preventive interventions are indicated
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Migraine frequency Number of attacks SSRIs or SNRIs vs placebo | no estimate extracted | 2 studies · 113 participants | Low Downgraded: risk of bias, imprecision |
Migraine intensity Score SSRIs or SNRIs vs placebo | no estimate extracted | 2 studies · 113 participants | Low Downgraded: risk of bias, imprecision |
Migraine duration Hours SSRIs or SNRIs vs placebo | no estimate extracted | 1 study · 60 participants | Ungraded |
Symptomatic/analgesic medication use for acute headache attacks SSRIs or SNRIs vs placebo | no estimate extracted | 2 studies · 113 participants | Low Downgraded: risk of bias, imprecision |
Migraine index SSRIs or SNRIs vs placebo | no estimate extracted | 3 studies · 86 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life SSRIs or SNRIs vs placebo | no estimate extracted | NR | No studies |
Withdrawn (due to adverse events) SSRIs or SNRIs vs placebo | OR 1.95 [0.7, 5.44] | 5 studies · 221 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
SSRIs or SNRIs compared to amitriptyline for migraine prevention
Population: patients for whom migraine preventive interventions are indicated
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Migraine frequency Number of attacks SSRIs or SNRIs vs amitriptyline | no estimate extracted | 2 studies · 96 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Migraine intensity Score SSRIs or SNRIs vs amitriptyline | no estimate extracted | 2 studies · 104 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Migraine duration Hours SSRIs or SNRIs vs amitriptyline | no estimate extracted | 2 studies · 104 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Symptomatic/analgesic medication use for acute headache attacks SSRIs or SNRIs vs amitriptyline | no estimate extracted | NR | No studies |
Migraine index Score SSRIs or SNRIs vs amitriptyline | no estimate extracted | 1 study · 62 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Quality of life SSRIs or SNRIs vs amitriptyline | no estimate extracted | NR | No studies |
Withdrawn (for any reasons and due to adverse events) SSRIs or SNRIs vs amitriptyline | OR 0.39 [0.1, 1.5] | 1 study · 64 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |