Cochrane · systematic review · CD005451
Carbamazepine for chronic neuropathic pain and fibromyalgia in adults
Wiffen, PJ, Derry, S, Moore, RA, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 75%Low 2 · 25%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: adults with neuropathic pain (Trigeminal neuralgia, painful diabetic neuropathy, chronic post stroke pain)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
"Substantial" benefit At least 50% reduction in pain or equivalent | RR 6.5 [3.4, 12] | 4 studies · 188 participants | Low |
"Moderate" benefit At least 30% reduction in pain | no estimate extracted | NR | Very low |
Proportion below 30/100 mm on VAS | no estimate extracted | NR | Very low |
Patient Global Impression of Change much or very much improved | no estimate extracted | NR | Very low |
Any adverse event | RR 2.4 [1.9, 3.2] | 4 studies · 346 participants | Low |
Adverse event withdrawals | no estimate extracted | 8 studies · 523 participants | Very low |
Serious adverse events | no estimate extracted | 2 studies · 46 participants | Very low |
Death | no estimate extracted | 1 study · 44 participants | Very low |