Cochrane · systematic review · CD012535
Antidepressants for chronic non‐cancer pain in children and adolescents
Cooper, TE, Heathcote, LC, Clinch, J, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
9
No studies
9
Included studies
NR
No studies 9 · 50%Ungraded 0 · 0%Very low 9 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Amitriptyline compared with gabapentin for chronic non‐cancer pain
Population: children and adolescents (birth to 17 years) with chronic non‐cancer pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 30% or greater Amitriptyline vs gabapentin | no estimate extracted | NR | No studies |
Participant‐reported pain relief of 50% or greater Amitriptyline vs gabapentin | no estimate extracted | NR | No studies |
Patient Global Impression of Change: much improved or very much improved Amitriptyline vs gabapentin | no estimate extracted | NR | No studies |
Adverse events Amitriptyline vs gabapentin | no estimate extracted | 1 study · 34 participants | Very low |
Serious adverse events Amitriptyline vs gabapentin | no estimate extracted | 1 study · 34 participants | Very low |
Withdrawals due to adverse events Amitriptyline vs gabapentin | no estimate extracted | 1 study · 34 participants | Very low |
Amitriptyline compared with placebo for chronic non‐cancer pain
Population: children and adolescents (birth to 17 years) with chronic non‐cancer pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 30% or greater Amitriptyline vs placebo | no estimate extracted | NR | No studies |
Participant‐reported pain relief of 50% or greater Amitriptyline vs placebo | no estimate extracted | NR | No studies |
Patient Global Impression of Change: much improved or very much improved Amitriptyline vs placebo | no estimate extracted | NR | No studies |
Adverse events Amitriptyline vs placebo | no estimate extracted | 2 studies · 123 participants | Very low |
Serious adverse events Amitriptyline vs placebo | no estimate extracted | 2 studies · 123 participants | Very low |
Withdrawals due to adverse events Amitriptyline vs placebo | no estimate extracted | 2 studies · 123 participants | Very low |
Citalopram compared with placebo for chronic non‐cancer pain
Population: children and adolescents with functional abdominal pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 30% or greater Citalopram vs placebo | no estimate extracted | NR | No studies |
Participant‐reported pain relief of 50% or greater Citalopram vs placebo | no estimate extracted | NR | No studies |
Patient Global Impression of Change: much improved or very much improved Citalopram vs placebo | no estimate extracted | NR | No studies |
Adverse events Citalopram vs placebo | no estimate extracted | 1 study · 115 participants | Very low |
Serious adverse events Citalopram vs placebo | no estimate extracted | 1 study · 115 participants | Very low |
Withdrawals due to adverse events Citalopram vs placebo | no estimate extracted | 1 study · 115 participants | Very low |