Cochrane · systematic review · CD012536
Antiepileptic drugs for chronic non‐cancer pain in children and adolescents
Cooper, TE, Wiffen, PJ, Heathcote, LC, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
9
No studies
3
Included studies
NR
No studies 3 · 25%Ungraded 0 · 0%Very low 9 · 75%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Gabapentin compared with amitriptyline for chronic non‐cancer pain
Population: children and adolescents (birth to 17 years of age) with chronic non‐cancer pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 30% or greater Gabapentin vs amitriptyline | no estimate extracted | NR | No studies |
Participant‐reported pain relief of 50% or greater Gabapentin vs amitriptyline | no estimate extracted | NR | No studies |
Patient Global Impression of Change: much improved or very much improved Gabapentin vs amitriptyline | no estimate extracted | NR | No studies |
Any adverse events Gabapentin vs amitriptyline | no estimate extracted | 1 study · 34 participants | Very low |
Serious adverse events Gabapentin vs amitriptyline | no estimate extracted | 1 study · 34 participants | Very low |
Withdrawals due to adverse events Gabapentin vs amitriptyline | no estimate extracted | 1 study · 34 participants | Very low |
Pregabalin compared with placebo for chronic non‐cancer pain
Population: children and adolescents (birth to 17 years of age) with chronic non‐cancer pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 30% or greater** Pregabalin vs placebo | no estimate extracted | 1 study · 107 participants | Very low |
Participant‐reported pain relief of 50% or greater** Pregabalin vs placebo | no estimate extracted | 1 study · 107 participants | Very low |
Patient Global Impression of Change: much improved or very much improved** Pregabalin vs placebo | no estimate extracted | 1 study · 107 participants | Very low |
Adverse events Pregabalin vs placebo | no estimate extracted | 1 study · 107 participants | Very low |
Serious adverse events Pregabalin vs placebo | no estimate extracted | 1 study · 107 participants | Very low |
Withdrawals due to adverse events Pregabalin vs placebo | no estimate extracted | 1 study · 107 participants | Very low |