Cochrane · systematic review · CD007355
Single dose oral ketoprofen or dexketoprofen for acute postoperative pain in adults
Gaskell, H, Derry, S, Wiffen, PJ, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
20
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 8 · 40%Low 0 · 0%Moderate 1 · 5%High 11 · 55%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ketoprofen 25 mg compared with placebo for acute postoperative pain
Population: adults with moderate or severe acute postoperative pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participants with ≥ 50% pain relief over 6 hours Ketoprofen 25 mg vs placebo | no estimate extracted | 8 studies · 535 participants | High |
Median (mean) time to use of rescue medication Ketoprofen 25 mg vs placebo | no estimate extracted | 2 studies · 188 participants | Very low |
Participants using rescue medication over 6 hours Ketoprofen 25 mg vs placebo | no estimate extracted | 6 studies · 402 participants | Moderate |
Participants with ≥ 1 adverse event following a single dose Ketoprofen 25 mg vs placebo | no estimate extracted | 7 studies · 490 participants | High |
Participants with a serious adverse event following a single dose Ketoprofen 25 mg vs placebo | no estimate extracted | 8 studies · 535 participants | Very low |
Ketoprofen 50 mg compared with placebo for acute postoperative pain
Population: adults with moderate or severe acute postoperative pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participants with ≥ 50% pain relief over 4‐6 hours Ketoprofen 50 mg vs placebo | no estimate extracted | 8 studies · 594 participants | High |
Median (mean) time to use of rescue medication Ketoprofen 50 mg vs placebo | no estimate extracted | 1 study · 77 participants | Very low |
Participants using rescue medication over 6 hours Ketoprofen 50 mg vs placebo | no estimate extracted | 4 studies · 263 participants | High |
Participants with ≥ 1 adverse event following a single dose Ketoprofen 50 mg vs placebo | no estimate extracted | 5 studies · 342 participants | High |
Participants with a serious adverse event following a single dose Ketoprofen 50 mg vs placebo | no estimate extracted | 9 studies · 688 participants | Very low |
Dexketoprofen 10 mg‐12.5 mg compared with placebo for acute postoperative pain
Population: adults with moderate or severe acute postoperative pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participants with ≥ 50% pain relief over 4‐6 hours Dexketoprofen 10 mg‐12.5 mg vs placebo | no estimate extracted | 5 studies · 480 participants | High |
Median (mean) time to use of rescue medication Dexketoprofen 10 mg‐12.5 mg vs placebo | no estimate extracted | 1 study · 122 participants | Very low |
Participants using rescue medication over 6 hours Dexketoprofen 10 mg‐12.5 mg vs placebo | no estimate extracted | 4 studies · 373 participants | High |
Participants with ≥ 1 adverse event following a single dose Dexketoprofen 10 mg‐12.5 mg vs placebo | no estimate extracted | 4 studies · 380 participants | High |
Participants with a serious adverse event following a single dose Dexketoprofen 10 mg‐12.5 mg vs placebo | no estimate extracted | 6 studies · 574 participants | Very low |
Dexketoprofen 20 mg or 25 mg compared with placebo for acute postoperative pain
Population: adults with moderate or severe acute postoperative pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participants with ≥ 50% pain relief over 4‐6 hours Dexketoprofen 20 mg or 25 mg vs placebo | no estimate extracted | 8 studies · 1177 participants | High |
Median (mean) time to use of rescue medication Dexketoprofen 20 mg or 25 mg vs placebo | no estimate extracted | 3 studies · 281 participants | Very low |
Participants using rescue medication over 6 hours Dexketoprofen 20 mg or 25 mg vs placebo | no estimate extracted | 5 studies · 445 participants | High |
Participants with ≥ 1 adverse event following a single dose Dexketoprofen 20 mg or 25 mg vs placebo | no estimate extracted | 6 studies · 536 participants | High |
Participants with a serious adverse event following a single dose Dexketoprofen 20 mg or 25 mg vs placebo | no estimate extracted | 9 studies · 1271 participants | Very low |