Cochrane · systematic review · CD012708
Mirtazapine for fibromyalgia in adults
Welsch, P, Bernardy, K, Derry, S, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mirtazapine compared with placebo for adult participants with fibromyalgia
Population: adult participants with fibromyalgia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain relief of 50% or greater (substantial improvement) Mirtazapine vs placebo | RD 0.05 | 3 studies · 591 participants | Low Downgraded: indirectness, publication bias |
Safety: serious adverse events Mirtazapine vs placebo | RD 0 | 3 studies · 606 participants | Very low Downgraded: imprecision, indirectness, publication bias |
Tolerability: withdrawals due to adverse events Mirtazapine vs placebo | RD 0.01 | 3 studies · 606 participants | Low Downgraded: indirectness, publication bias |
Participant‐reported pain relief of 30% or greater (moderate improvement) Mirtazapine vs placebo | RD 0.13 [0.05, 0.21] | 3 studies · 591 participants | Low Downgraded: indirectness, publication bias |
Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) Mirtazapine vs placebo | no estimate extracted | 3 studies · 573 participants | Low Downgraded: indirectness, publication bias |
Somnolence Mirtazapine vs placebo | RD 0.24 [0.18, 0.3] | 3 studies · 606 participants | Low Downgraded: indirectness, publication bias |
Weight gain Mirtazapine vs placebo | RD 0.17 [0.11, 0.23] | 3 studies · 606 participants | Low Downgraded: indirectness, publication bias |