Cochrane · systematic review · CD003971
Methadone for cancer pain
Nicholson, AB, Watson, GR, Derry, S, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
2
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Methadone compared to Morphine for cancer pain
Population: people with cancer pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐reported pain intensity Methadone vs Morphine | OR 76 | 103 participants | Low Downgraded: risk of bias, imprecision |
Adverse events: appetite, thirst, somnolence Methadone vs Morphine | no estimate extracted | 5 studies · 342 participants | Very low Downgraded: risk of bias, imprecision, indirectness |