Cochrane · systematic review · CD007393
Topical capsaicin (high concentration) for chronic neuropathic pain in adults
Derry, S, Rice, ASC, Cole, P, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
8
No studies
1
Included studies
NR
No studies 1 · 11.1%Ungraded 0 · 0%Very low 2 · 22.2%Low 0 · 0%Moderate 6 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
High‐concentration (8%) capsaicin patch compared with control patch (0.4%) for postherpetic neuralgia
Population: adults with postherpetic neuralgia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Substantial benefit High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | NR | No studies |
PGICvery much improved, week 8 and week 12 High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | NR | Very low |
Moderate benefit High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | NR | Moderate |
PGICmuch or very much improved, week 8 High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | 2 studies · 571 participants | Moderate |
PGIC much or very much improved, week 12 High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | 2 studies · 571 participants | Moderate |
Withdrawals due to lack of efficacy High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | 6 studies · 2073 participants | Moderate |
Withdrawals due to adverse events High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | 8 studies · 2487 participants | Moderate |
Serious adverse events High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | 7 studies · 1993 participants | Moderate |
Death High‐concentration (8%) capsaicin patch vs control patch (0.4%) | no estimate extracted | 8 studies · 2487 participants | Very low |