Cochrane · systematic review · CD011669
Morphine for chronic neuropathic pain in adults
Cooper, TE, Chen, J, Wiffen, PJ, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 8 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Morphine compared with placebo for neuropathic pain
Population: adults with neuropathic pain (any origin)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reported outcomes approximating to 30% reduction in pain Morphine vs placebo | no estimate extracted | 62 participants | Very low |
At least 50% reduction in pain Morphine vs placebo | no estimate extracted | 62 participants | Very low |
PGIC much or very much improved Morphine vs placebo | no estimate extracted | 1 study · 32 participants | Very low |
Any pain‐related outcome (moderate pain improvement) Morphine vs placebo | RD 0.27 [0.16, 0.38] | 4 studies · 263 participants | Very low |
Serious adverse events Morphine vs placebo | no estimate extracted | 4 studies · 289 participants | Very low |
Death Morphine vs placebo | no estimate extracted | 4 studies · 289 participants | Very low |
Any adverse event Morphine vs placebo | no estimate extracted | 4 studies · 289 participants | Very low |
All‐cause withdrawal Morphine vs placebo | RD 0.04 | 4 studies · 289 participants | Very low |