Cochrane · systematic review · CD012499
Methadone for neuropathic pain in adults
McNicol, ED, Ferguson, MC, Schumann, R · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 6 · 85.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Methadone compared with placebo for neuropathic pain
Population: adults with chronic neuropathic pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Moderate benefit:at least 30% reductionin pain, orPGIC much or verymuch improved Methadone vs placebo | no estimate extracted | 2 studies · 29 participants | Very low |
Substantial benefit:at least 50% reductionin pain, orPGIC much improved Methadone vs placebo | no estimate extracted | 1 study · 19 participants | Very low |
Withdrawals due to lack of efficacy Methadone vs placebo | no estimate extracted | 2 studies · 29 participants | Very low |
Withdrawals due toadverse event withdrawal Methadone vs placebo | no estimate extracted | 2 studies · 29 participants | Very low |
Participants experiencing anyserious adverseevents Methadone vs placebo | no estimate extracted | NR | Very low |
Deaths Methadone vs placebo | no estimate extracted | NR | Very low |
CI: confidence interval. Methadone vs placebo | no estimate extracted | NR | No studies |