Cochrane Review Group

Neonatal

210 systematic reviews in Neonatal ask 2,353 questions. 18.4% have no studies to answer them, 25.9% rest on very low certainty evidence and 20.3% reach moderate or high certainty.

Reviews

210

Questions

2,353

current versions

No studies

18.4%

Moderate or high

20.3%

No studies 432 · 18.4%Ungraded 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Neonatal

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Summary of findings table ‐ Salbutamol vs placebo Adverse effects of bronchodilators, including hypokalaemia, tachycardia, cardiac arrhythmia, tremor, hypertension and hyperglycaemia ‐ not reported · preterm infants (< 37 weeks GA) at risk of chronic lung disease Inhaled bronchodilators for the prevention and treatment of chronic lung disease in preterm infants (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Salbutamol vs placebo Pneumothorax · preterm infants (< 37 weeks GA) at risk of chronic lung disease Inhaled bronchodilators for the prevention and treatment of chronic lung disease in preterm infants (2024) · Cochrane	no estimate extracted	1 study · 173 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Pulmonary air leak, any (during first hospitalisation) Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	RR 2.56 [0.11, 59.75]	1 study · 48 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Bronchopulmonary dysplasia (clinical definition) among survivors · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	NR	No studies
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Intraventricular haemorrhage grade III and IV Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	RR 2.56 [0.11, 59.75]	1 study · 48 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Death (all causes) during the first hospitalisation Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	RR 0.17 [0.01, 3.37]	1 study · 48 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Neurosensory disability in survivors · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	NR	No studies
Surfactant administration via laryngeal mask airway (S‐LMA) vs no surfactant administration Intraventricular haemorrhage grade III and IV Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	1 study · 103 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs no surfactant administration Death (all causes) during the first hospitalisation Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	1 study · 103 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs no surfactant administration Neurosensory disability in survivors · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	NR	No studies
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE) Intraventricular haemorrhage grade III and IV Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	1 study · 50 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE) Neurosensory disability in survivors · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 210

Stopping enteral feeds for prevention of transfusion‐associated necrotising enterocolitis in preterm infants

Yeo, KT, Kong, JY, et al. · Cochrane Database of Systematic Reviews · 2019

Neonatal

Thinnest evidence

Reviews 210

Stopping enteral feeds for prevention of transfusion‐associated necrotising enterocolitis in preterm infants

Human milk‐derived fortifier versus bovine milk‐derived fortifier for prevention of mortality and morbidity in preterm neonates

Lipid emulsions for parenterally fed preterm infants

Lipid emulsions for parenterally fed term and late preterm infants

Immunoglobulin for alloimmune hemolytic disease in neonates

Laryngeal mask airway versus bag‐mask ventilation or endotracheal intubation for neonatal resuscitation

Naloxone for opioid‐exposed newborn infants

Infant formulas containing hydrolysed protein for prevention of allergic disease

Interventions to prevent hypothermia at birth in preterm and/or low birth weight infants

Higher versus lower amino acid intake in parenteral nutrition for newborn infants

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates

Anti‐vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity

Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Beta‐blockers for prevention and treatment of retinopathy of prematurity in preterm infants

Pulse oximetry screening for critical congenital heart defects

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants

Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants

Provision of respiratory support compared to no respiratory support before cord clamping for preterm infants

Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants

Xenon as an adjuvant to therapeutic hypothermia in near‐term and term newborns with hypoxic‐ischaemic encephalopathy

Repeated lumbar or ventricular punctures in newborns with intraventricular haemorrhage

Long chain polyunsaturated fatty acid supplementation in infants born at term

Nitric oxide for respiratory failure in infants born at or near term

Inhaled nitric oxide for respiratory failure in preterm infants

Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm neonates