Cochrane · systematic review · CD012519
Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants
Grev, J, Berg, M, Soll, R · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
13
No studies
4
Included studies
NR
No studies 4 · 23.5%Ungraded 0 · 0%Very low 2 · 11.8%Low 11 · 64.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Probiotics administered to pregnant women at risk of preterm birth compared to placebo or no intervention for prevention of morbidity and mortality in preterm infants
Population: prevention of morbidity and mortality in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm birth < 37 weeks' gestation Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | RR 0.92 [0.32, 2.67] | 4 studies · 518 participants | Low Downgraded: risk of bias, indirectness |
Preterm birth < 34 weeks' gestation Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | no estimate extracted | 2 studies · 287 participants | Very low Downgraded: risk of bias, indirectness |
Gestational age at birth (weeks) Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | no estimate extracted | 2 studies · 207 participants | Low Downgraded: risk of bias, indirectness |
Death Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | no estimate extracted | 2 studies · 298 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Miscarriage/stillbirth Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | RR 0.79 [0.2, 3.14] | 2 studies · 320 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Neonatal sepsis ≤ 3 days Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | no estimate extracted | 1 study · 162 participants | Very low Downgraded: risk of bias, indirectness |
Severe necrotizing enterocolitis (NEC) (Bell stage II or more) Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | no estimate extracted | NR | No studies |
Death or severe NEC Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | no estimate extracted | NR | No studies |
Late‐onset sepsis Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | no estimate extracted | NR | No studies |
Culture‐proven sepsis with supplemented probiotic Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention | no estimate extracted | NR | No studies |
Probiotics administered exclusively after birth in mothers of preterm infants compared to maternal placebo or no intervention for prevention of morbidity and mortality in preterm infants
Population: prevention of morbidity and mortality in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any necrotizing Enterocolitis (NEC) Probiotics administered exclusively after birth in mothers of preterm infants vs maternal placebo or no intervention | RR 0.44 [0.13, 1.46] | 1 study · 58 participants | Low Downgraded: imprecision |
Death prior to hospital discharge Probiotics administered exclusively after birth in mothers of preterm infants vs maternal placebo or no intervention | RR 0.66 [0.06, 6.88] | 1 study · 58 participants | Low Downgraded: imprecision |
Death or NEC Probiotics administered exclusively after birth in mothers of preterm infants vs maternal placebo or no intervention | RR 0.53 [0.19, 1.49] | 1 study · 58 participants | Low Downgraded: imprecision |
Surgery for NEC Probiotics administered exclusively after birth in mothers of preterm infants vs maternal placebo or no intervention | RR 0.15 [0.01, 2.58] | 1 study · 58 participants | Low Downgraded: imprecision |
Neonatal sepsis Probiotics administered exclusively after birth in mothers of preterm infants vs maternal placebo or no intervention | RR 1.32 [0.48, 3.61] | 1 study · 58 participants | Low Downgraded: imprecision |
Culture‐proven sepsis with probiotic organism Probiotics administered exclusively after birth in mothers of preterm infants vs maternal placebo or no intervention | no estimate extracted | 1 study · 58 participants | Low Downgraded: imprecision |
Feeding with more than 50% breast milk (days) Probiotics administered exclusively after birth in mothers of preterm infants vs maternal placebo or no intervention | no estimate extracted | 1 study · 58 participants | Low Downgraded: imprecision |