Cochrane · systematic review · CD000399
Nitric oxide for respiratory failure in infants born at or near term
Barrington, KJ, Finer, N, Pennaforte, T, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 16.7%Moderate 7 · 58.3%High 3 · 25%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled NO compared with control for respiratory failure in infants born at or near term
Population: respiratory failure in infants born at or near term
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or use of ECMO; studies that did not allow back‐up use of iNO in controls Inhaled NO vs control | RR 0.66 [0.57, 0.77] | 8 studies · 859 participants | High |
Death or use of ECMO; infants with diaphragmatic hernia Inhaled NO vs control | RR 1.09 [0.95, 1.26] | 2 studies · 84 participants | Moderate Downgraded: imprecision |
Death before hospital discharge; studies that did not allow back‐up use of iNO in controls Inhaled NO vs control | RR 0.89 [0.6, 1.31] | 8 studies · 860 participants | High |
Death before hospital discharge; infants with diaphragmatic hernia Inhaled NO vs control | RR 1.2 [0.74, 1.96] | 2 studies · 84 participants | Moderate Downgraded: imprecision |
Use of ECMO before hospital discharge; studies that did not allow back‐up use of iNO in controls Inhaled NO vs control | RR 0.6 [0.5, 0.71] | 7 studies · 815 participants | High |
Use of ECMO before hospital discharge; infants with diaphragmatic hernia Inhaled NO vs control | RR 1.27 [1, 1.62] | 2 studies · 84 participants | Moderate Downgraded: imprecision |
Neurodevelopmental disability at 18 to 24 months among survivors Inhaled NO vs control | RR 0.97 [0.66, 1.44] | 2 studies · 301 participants | Low Downgraded: imprecision |
Inhaled NO at moderate compared with severe criteria for illness severity in respiratory failure among infants born at or near term
Population: infants born at or near term in respiratory failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or requirement for ECMO Inhaled NO at moderate vs severe criteria | RR 0.88 [0.62, 1.27] | 5 studies · 495 participants | Low |
Death before hospital discharge Inhaled NO at moderate vs severe criteria | RR 0.69 [0.38, 1.26] | 5 studies · 495 participants | Moderate Downgraded: imprecision |
Use of ECMO before hospital discharge Inhaled NO at moderate vs severe criteria | RR 1.01 [0.66, 1.54] | 4 studies · 439 participants | Moderate Downgraded: imprecision |
Progression to severe criteria Inhaled NO at moderate vs severe criteria | RR 0.66 [0.55, 0.79] | 6 studies · 512 participants | Moderate Downgraded: imprecision |
Neurodevelopmental disability at 18 to 24 months among survivors Inhaled NO at moderate vs severe criteria | RR 1.13 [0.74, 1.74] | 1 study · 234 participants | Moderate Downgraded: imprecision |