Cochrane Review Group

Neonatal

210 systematic reviews in Neonatal ask 2,353 questions. 18.4% have no studies to answer them, 25.9% rest on very low certainty evidence and 20.3% reach moderate or high certainty.

Reviews

210

Questions

2,353

current versions

No studies

18.4%

Moderate or high

20.3%

No studies 432 · 18.4%Ungraded 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Neonatal

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Summary of findings table ‐ Salbutamol vs placebo Adverse effects of bronchodilators, including hypokalaemia, tachycardia, cardiac arrhythmia, tremor, hypertension and hyperglycaemia ‐ not reported · preterm infants (< 37 weeks GA) at risk of chronic lung disease Inhaled bronchodilators for the prevention and treatment of chronic lung disease in preterm infants (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Salbutamol vs placebo Pneumothorax · preterm infants (< 37 weeks GA) at risk of chronic lung disease Inhaled bronchodilators for the prevention and treatment of chronic lung disease in preterm infants (2024) · Cochrane	no estimate extracted	1 study · 173 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Pulmonary air leak, any (during first hospitalisation) Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	RR 2.56 [0.11, 59.75]	1 study · 48 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Bronchopulmonary dysplasia (clinical definition) among survivors · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	NR	No studies
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Intraventricular haemorrhage grade III and IV Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	RR 2.56 [0.11, 59.75]	1 study · 48 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Death (all causes) during the first hospitalisation Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	RR 0.17 [0.01, 3.37]	1 study · 48 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with extubation at standard criteria (S‐ETT) Neurosensory disability in survivors · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	NR	No studies
Surfactant administration via laryngeal mask airway (S‐LMA) vs no surfactant administration Intraventricular haemorrhage grade III and IV Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	1 study · 103 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs no surfactant administration Death (all causes) during the first hospitalisation Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	1 study · 103 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs no surfactant administration Neurosensory disability in survivors · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	NR	No studies
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE) Intraventricular haemorrhage grade III and IV Anytime to discharge · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	1 study · 50 participants	Very low
Surfactant administration via laryngeal mask airway (S‐LMA) vs surfactant administration via endotracheal tube (ETT) with the intent to rapidly extubate (InSurE) Neurosensory disability in survivors · preterm infants with or at risk of respiratory distress syndrome Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants… (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 210

Longchain polyunsaturated fatty acid supplementation in preterm infants

Moon, K, Rao, SC, et al. · Cochrane Database of Systematic Reviews · 2016

Neonatal

Thinnest evidence

Reviews 210

Longchain polyunsaturated fatty acid supplementation in preterm infants

Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants

Sucrose for analgesia in newborn infants undergoing painful procedures

Non‐nutritive sucking for increasing physiologic stability and nutrition in preterm infants

Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia

Glutamine supplementation to prevent morbidity and mortality in preterm infants

Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates

Kangaroo mother care to reduce morbidity and mortality in low birthweight infants

Infant position in neonates receiving mechanical ventilation

Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge

One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates

Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed

Responsive versus scheduled feeding for preterm infants

Cycled light in the intensive care unit for preterm and low birth weight infants

Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Co‐bedding in neonatal nursery for promoting growth and neurodevelopment in stable preterm twins

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants

Antimicrobial dressings for the prevention of catheter‐related infections in newborn infants with central venous catheters

Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants

Heparin for the prevention of intraventricular haemorrhage in preterm infants

Epinephrine for transient tachypnea of the newborn

Rescue high‐frequency jet ventilation versus conventional ventilation for severe pulmonary dysfunction in preterm infants

Regional (spinal, epidural, caudal) versus general anaesthesia in preterm infants undergoing inguinal herniorrhaphy in early infancy

Intravenous in‐line filters for preventing morbidity and mortality in neonates