Cochrane · systematic review · CD005091
One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates
Rao, SC, Srinivasjois, R, Moon, K · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 20%Very low 2 · 40%Low 0 · 0%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: neonates with suspected or proven sepsis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clearance of proven sepsis | RR 1 [0.84, 1.19] | 3 studies · 37 participants | Very low |
Failure to achieve peak levels of at least 5 microgram/ml (measured 0.5 to one hour after administration of any dose of gentamicin) | RR 0.22 [0.11, 0.47] | 9 studies · 422 participants | Moderate |
Nephrotoxicity (End of study period or before discharge) | no estimate extracted | 8 studies · 348 participants | Ungraded |
Ototoxicity (End of study period or before discharge) | RR 1.69 [0.18, 16.25] | 5 studies · 214 participants | Very low |
Failure to achieve trough levels of ≤2 microgram/ml ( | RR 0.38 [0.27, 0.55] | 11 studies · 503 participants | Moderate |