Cochrane · systematic review · CD010112
Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy
Schindler, T, Sinn, JKH, Osborn, DA · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 13 · 92.9%Low 1 · 7.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Higher versus lower PUFA intake for the prevention of allergy ‐ infant incidence
Population: infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All allergic disease ‐ infant incidence Higher vs lower PUFA intake | RR 0.96 [0.73, 1.26] | 1 study · 323 participants | Very low Downgraded: imprecision |
Asthma ‐ infant incidence Higher vs lower PUFA intake | RR 1.04 [0.8, 1.35] | 3 studies · 1162 participants | Low |
Dermatitis/eczema ‐ infant incidence Higher vs lower PUFA intake | RR 0.93 [0.82, 1.06] | 7 studies · 1906 participants | Very low Downgraded: imprecision |
Allergic rhinitis ‐ infant incidence Higher vs lower PUFA intake | RR 0.47 [0.23, 0.96] | 2 studies · 594 participants | Very low Downgraded: imprecision |
Food allergy ‐ infant incidence Higher vs lower PUFA intake | RR 0.81 [0.56, 1.19] | 3 studies · 915 participants | Very low Downgraded: imprecision, inconsistency |
Higher versus lower PUFA intake for the prevention of allergy ‐ childhood incidence
Population: infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All allergic disease ‐ childhood incidence Higher vs lower PUFA intake | RR 0.69 [0.47, 1.02] | 2 studies · 154 participants | Very low Downgraded: imprecision, inconsistency |
Asthma ‐ childhood incidence Higher vs lower PUFA intake | RR 0.45 [0.2, 1.02] | 1 study · 89 participants | Very low Downgraded: imprecision |
Dermatitis/eczema ‐ childhood incidence Higher vs lower PUFA intake | RR 0.65 [0.34, 1.24] | 2 studies · 154 participants | Very low Downgraded: imprecision |
Food allergy ‐ childhood incidence Higher vs lower PUFA intake | RR 2.27 [0.25, 20.68] | 1 study · 65 participants | Very low Downgraded: imprecision |
Higher versus lower PUFA intake for the prevention of allergy ‐ Childhood prevalence
Population: infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All allergic disease ‐ childhood prevalence Higher vs lower PUFA intake | RR 0.98 [0.81, 1.19] | 2 studies · 633 participants | Very low Downgraded: imprecision |
Asthma ‐ childhood prevalence Higher vs lower PUFA intake | RR 1.12 [0.82, 1.53] | 2 studies · 635 participants | Very low Downgraded: imprecision |
Dermatitis/eczema ‐ childhood prevalence Higher vs lower PUFA intake | RR 0.81 [0.59, 1.09] | 2 studies · 635 participants | Very low Downgraded: imprecision |
Allergic rhinitis ‐ childhood prevalence Higher vs lower PUFA intake | RR 1.02 [0.83, 1.25] | 2 studies · 635 participants | Very low Downgraded: imprecision |
Food allergy ‐ childhood prevalence Higher vs lower PUFA intake | RR 0.27 [0.06, 1.19] | 1 study · 119 participants | Very low Downgraded: imprecision |