Cochrane · systematic review · CD001816
Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates
Foster, JP, Seth, R, Cole, MJ · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table for oral immunoglobulin versus control
Population: preventing necrotizing enterocolitis in preterm and low birth weight neonates
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Definite necrotizing enterocolitis (NEC) during study period Summary of findings table for oral immunoglobulin vs control | RR 0.84 [0.57, 1.25] | 3 studies · 1840 participants | Low Downgraded: risk of bias |
Definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG Summary of findings table for oral immunoglobulin vs control | RR 0.08 [0, 1.39] | 1 study · 179 participants | Very low Downgraded: risk of bias |
Definite necrotizing enterocolitis (NEC) during study period ‐ IgG Summary of findings table for oral immunoglobulin vs control | RR 0.95 [0.63, 1.42] | 2 studies · 1661 participants | Low Downgraded: risk of bias, imprecision |
Definite NEC after study period Summary of findings table for oral immunoglobulin vs control | RR 1.3 [0.47, 3.6] | 2 studies · 1661 participants | Very low Downgraded: risk of bias, imprecision |
NEC‐related surgery during study period Summary of findings table for oral immunoglobulin vs control | RR 0.21 [0.02, 1.75] | 2 studies · 311 participants | Very low Downgraded: risk of bias |
NEC‐related deaths during study period Summary of findings table for oral immunoglobulin vs control | RR 1.1 [0.47, 2.59] | 3 studies · 1840 participants | Very low Downgraded: risk of bias |