Cochrane · systematic review · CD001457

Glutamine supplementation to prevent morbidity and mortality in preterm infants

Moe‐Byrne, T, Brown, JVE, McGuire, W · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

Neonatal2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 25%Moderate 2 · 50%High 1 · 25%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Glutamine supplementation to prevent morbidity and mortality in preterm infants

Population: Preterm infants
4 questions
OutcomeEffectEvidenceStatus / GRADE
Death prior to hospital discharge
RR 0.97 [0.8, 1.17]12 studies · 2877 participantsHigh
Neurodevelopmental impairment
RR 1.07 [0.59, 1.92]1 study · 72 participantsLow
Downgraded: imprecision, inconsistency, publication bias
Invasive infection
RR 0.94 [0.86, 1.04]11 studies · 2815 participantsModerate
Downgraded: imprecision, inconsistency, publication bias
Necrotising enterocolitis
RR 0.83 [0.66, 1.06]11 studies · 2849 participantsModerate
Downgraded: imprecision, inconsistency, publication bias