Cochrane · systematic review · CD001240
Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia
Young, L, Berg, M, Soll, R · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Barbiturate treatment compared to placebo or no treatment
Population: infants with perinatal asphyxia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or major neurodevelopmental disability Barbiturate treatment vs placebo or no treatment | RR 0.33 [0.14, 0.78] | 1 study · 31 participants | Very low Downgraded: risk of bias |
Death Barbiturate treatment vs placebo or no treatment | RR 0.88 [0.55, 1.42] | 8 studies · 429 participants | Low Downgraded: risk of bias |
Major neurodevelopmental disability Barbiturate treatment vs placebo or no treatment | RR 0.24 [0.06, 0.92] | 1 study · 31 participants | Very low Downgraded: risk of bias |
Cerebral palsy Barbiturate treatment vs placebo or no treatment | RR 0.58 [0.19, 1.7] | 2 studies · 69 participants | Very low Downgraded: risk of bias |
Developmental delay Barbiturate treatment vs placebo or no treatment | RR 0.54 [0.24, 1.19] | 2 studies · 63 participants | Very low Downgraded: risk of bias |
Seizures (clinical or electrographic) Barbiturate treatment vs placebo or no treatment | RR 0.62 [0.48, 0.81] | 6 studies · 319 participants | Low Downgraded: risk of bias |
Abnormal neurologic exam at discharge Barbiturate treatment vs placebo or no treatment | RR 0.85 [0.67, 1.08] | 4 studies · 245 participants | Low Downgraded: risk of bias |