Sucrose for analgesia in newborn infants undergoing painful procedures

PIPP at 30 s after heel lance Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA. A lower score = less pain (Stevens 1996)

PIPP at 60 s after heel lance Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants >3 6 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP score during heel lance (1st heel lance) Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

DAN score at 30 s after heel lance Range of scale 0‐10 A lower score = less pain (Carbajal 1997)

NIPS during heel lance Range of scale 0‐7 A lower score = less pain Lawrence 1993

PIPP ‐ Preterm infants

NFCS Range of scale 0‐10 in term infants 0‐9 in preterm infants A lower score = less pain Grunau 1987

PIPP 30 s after heel lance (term and preterm infants) Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP 60 s after heel lance Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP score Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP score Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

NIPS score Range of scale 0‐7 A lower score = less pain Lawrence 1993

Revised NFCS Range of scale 0‐10 in term infants 0‐9 in preterm infants A lower score = less pain Grunau 1987

Revised NFCS Range of scale 0‐10 in term infants 0‐9 in preterm infants A lower score = less pain Grunau 1987

Revised NFCS Range of scale 0‐10 in term infants 0‐9 in preterm infants A lower score = less pain Grunau 1987

Total Bernese Pain Scale for Neonates (BPSN) during heel lance

Total Bernese Pain Scale for Neonates during recovery from heel lance

Total Bernese Pain Scale for Neonates during heel lance (preterm infants)

Total Bernese Pain Scale for Neonates during recovery (preterm infants)

NIPS score in term and preterm infants Range of scale 0‐7 A lower score = less pain Lawrence 1993

PIPP score during venipuncture Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP score Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP score during post‐injection period Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

DAN score during venipuncture (preterm infants) Range of scale 0‐10 A lower score = less pain (Carbajal 1997)

DAN score during the post‐injection period Range of scale 0‐10 A lower score = less pain (Carbajal 1997)

NIPS during 1‐2 minutes after IM injection Range of scale 0‐7 A lower score = less pain Lawrence 1993

PIPP during IM injection (term infants) ‐ Infants of non‐diabetic and diabetic mothers Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

NIPS during 1‐2 minutes after immunization Range of scale 0‐7 A lower score = less pain Lawrence 1993

Change in DAN score Range of scale 0‐10 A lower score = less pain (Carbajal 1997)

PIPP score intra procedure Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP score 30 seconds post procedure Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP score 1 min post procedure Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP during exam Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

PIPP score during eye examination Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a)

N‐PASS score during circumcision Range of scale 0‐13 A lower score = less pain (Hummel 2010)

N‐PASS score after 5 min Range of scale 0‐13 A lower score = less pain (Hummel 2010)

N‐PASS score during circumcision Range 0‐13 A lower score = less pain (Hummel 2010)

N‐PASS score after 5 min Range 0‐13 A lower score = less pain (Hummel 2010)

PIPP

Motor development and vigor (MDV) domain of the NAPI tool Normative mean and SD at 36 weeks PMA 63 (14.5) Higher scores are associated with more mature behaviour (Snider 2005)

Alertness and orientation (AO) domain of the NAPI tool Normative mean and SD at 36 weeks PMA 54 (19.4) Higher scores are associated with more mature behaviour (Snider 2005)