Cochrane · systematic review · CD010531
Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants
More, K, Athalye‐Jape, GK, Rao, SC, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 9 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Neonates with PPHN
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death from any cause prior to hospital discharge | RR 0.2 [0.02, 1.77] | 37 participants | Low |
Percentage of infants that showed improvement in OI by at least 20% by the end of therapy | no estimate extracted | 39 participants | Low |
Adverse neurological outcomes at six months of age | no estimate extracted | 37 participants | Low |
Cerebral Palsy | no estimate extracted | 37 participants | Low |
Deafness | no estimate extracted | 37 participants | Low |
Need for ECMO prior to discharge | no estimate extracted | 21 participants | Low |
Comparison
Population: Neonates with PPHN
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total duration of mechanical ventilation (days) | no estimate extracted | 37 participants | Low |
Comparison
Population: Neonates with PPHN
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of iNO therapy (days) | no estimate extracted | 21 participants | Low |
Total duration of mechanical ventilation (days) | no estimate extracted | 21 participants | Low |