Cochrane · systematic review · CD007480
Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Imdad, A, Ahmed, Z, Bhutta, ZA · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 3 · 42.9%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsVitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Population: infants 1 to 6 months of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality: longest | RR 1.05 [0.89, 1.25] | 9 studies · 21339 participants | Moderate Downgraded: imprecision |
Morbidity: diarrhoea: point prevalence | RR 0.99 [0.93, 1.05] | 2 studies · 9891 participants | Moderate Downgraded: imprecision |
Adverse effects: bulging fontanelle within 48 to 72 hours | RR 3.1 [1.89, 5.09] | 9 studies · 13493 participants | High |
Adverse effects: vomiting 48 to 72 hours | RR 0.95 [0.67, 1.35] | 2 studies · 2187 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects: diarrhoea 48 to 72 hours | RR 1.07 [0.82, 1.4] | 3 studies · 2176 participants | Low Downgraded: imprecision |
Adverse effects: fever 48 to 72 hours | RR 0.94 [0.83, 1.07] | 3 studies · 3187 participants | Low Downgraded: imprecision |
Vitamin A deficiency: retinol < 0.7 μmol/L | RR 0.86 [0.7, 1.06] | 4 studies · 1204 participants | Moderate Downgraded: imprecision |