Cochrane · systematic review · CD000501
Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants
Darlow, BA, Graham, PJ, Rojas‐Reyes, MX · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 6 · 85.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Supplemental vitamin A compared to no supplementation in very low birth weight infants
Population: very low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal death Supplemental vitamin A vs no supplementation | RR 0.86 [0.66, 1.11] | 6 studies · 1165 participants | Moderate Downgraded: imprecision |
Chronic lung disease (oxygen use at 28 days in survivors) Supplemental vitamin A vs no supplementation | RR 0.93 [0.86, 1.01] | 7 studies · 1070 participants | Moderate Downgraded: imprecision |
Death or chronic lung disease (oxygen use at 28 days) Supplemental vitamin A vs no supplementation | RR 0.93 [0.88, 0.99] | 6 studies · 1165 participants | Moderate Downgraded: imprecision |
Death before 36 weeks' postmenstrual age Supplemental vitamin A vs no supplementation | RR 1 [0.77, 1.29] | 4 studies · 1089 participants | Moderate Downgraded: imprecision |
Chronic lung disease (oxygen use at 36 weeks' postmenstrual age in survivors) Supplemental vitamin A vs no supplementation | RR 0.87 [0.77, 0.99] | 5 studies · 986 participants | Moderate Downgraded: imprecision |
Death or chronic lung disease (oxygen use at 36 weeks' postmenstrual age) Supplemental vitamin A vs no supplementation | RR 0.92 [0.84, 1.01] | 4 studies · 1089 participants | Moderate Downgraded: imprecision |
Neurodevelopmental impairment at 18 to 22 months Supplemental vitamin A vs no supplementation | RR 0.89 [0.74, 1.08] | 1 study · 538 participants | Low Downgraded: imprecision |