Cochrane · systematic review · CD008342
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates
Ardell, S, Offringa, M, Ovelman, C, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
21
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 21 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intramuscular vitamin K versus intravenous vitamin K
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bleeding complications: 0.2 mg IV versus 0.2 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 7 [0.38, 129.11] | 1 study · 52 participants | Low Downgraded: imprecision |
Bleeding complications: 0.2 mg IV versus 0.5 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 0.81 [0.2, 3.27] | 1 study · 54 participants | Low Downgraded: imprecision |
Intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.2 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 2 [0.19, 20.72] | 1 study · 52 participants | Low Downgraded: imprecision |
Intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.5 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 0.72 [0.13, 3.96] | 1 study · 54 participants | Low Downgraded: imprecision |
Presence of PIVKA II at day 5: 0.2 mg IV versus 0.2 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 1.52 [0.37, 6.23] | 1 study · 60 participants | Low Downgraded: imprecision |
Presence of PIVKA II at day 5: 0.2 mg IV versus 0.5 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 2.07 [0.41, 10.43] | 1 study · 57 participants | Low Downgraded: imprecision |
Presence of PIVKA II at day 25: 0.2 mg IV versus 0.2 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 1.08 [0.07, 16.36] | 1 study · 52 participants | Low Downgraded: imprecision |
Presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 1.04 [0.07, 15.74] | 1 study · 51 participants | Low Downgraded: imprecision |
Necrotizing enterocolitis ‐ 0.2 mg IV versus 0.2 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 1 [0.15, 6.57] | 1 study · 52 participants | Low Downgraded: imprecision |
Necrotizing enterocolitis: 0.2 mg IV versus 0.5 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 1.08 [0.16, 7.1] | 1 study · 54 participants | Low Downgraded: imprecision |
Sepsis: 0.2 mg IV versus 0.2 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 1 [0.28, 3.58] | 1 study · 52 participants | Low Downgraded: imprecision |
Sepsis: 0.2 mg IV versus 0.5 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 0.86 [0.26, 2.86] | 1 study · 54 participants | Low Downgraded: imprecision |
Mortality (all infants): 0.2 mg IV versus 0.2 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 1.32 [0.56, 3.14] | 1 study · 67 participants | Low Downgraded: imprecision |
Mortality (all infants): 0.2 mg IV versus 0.5 mg IM Intramuscular vitamin K vs intravenous vitamin K | RR 2.82 [0.84, 9.46] | 1 study · 64 participants | Low Downgraded: imprecision |
Higher dose vitamin K compared to lower dose vitamin K for preterm infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bleeding complications: 0.2 mg IM versus 0.5 mg IM Higher dose vitamin K vs lower dose vitamin K | RR 0.12 [0.01, 2.11] | 1 study · 54 participants | Low Downgraded: imprecision |
Intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM Higher dose vitamin K vs lower dose vitamin K | RR 0.36 [0.04, 3.24] | 1 study · 54 participants | Low Downgraded: imprecision |
Presence of PIVKA II at day 5: 0.2 mg IM versus 0.5 mg IM Higher dose vitamin K vs lower dose vitamin K | RR 1.36 [0.24, 7.57] | 1 study · 61 participants | Low Downgraded: imprecision |
Presence of PIVKA II at day 25: 0.2 mg IM versus 0.5 mg IM Higher dose vitamin K vs lower dose vitamin K | RR 0.96 [0.06, 14.6] | 1 study · 53 participants | Low Downgraded: imprecision |
Necrotizing enterocolitis: 0.2 mg IM versus 0.5 mg IM Higher dose vitamin K vs lower dose vitamin K | RR 1.08 [0.16, 7.1] | 1 study · 54 participants | Low Downgraded: imprecision |
Sepsis: 0.2 mg IM versus 0.5 mg IM Higher dose vitamin K vs lower dose vitamin K | RR 0.86 [0.26, 2.86] | 1 study · 54 participants | Low Downgraded: imprecision |
Mortality (all infants): 0.2 mg IM versus 0.5 mg IM Higher dose vitamin K vs lower dose vitamin K | RR 2.13 [0.6, 7.51] | 1 study · 65 participants | Low Downgraded: imprecision |