Cochrane · systematic review · CD000509
Inhaled nitric oxide for respiratory failure in preterm infants
Barrington, KJ, Finer, N, Pennaforte, T · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 36.4%High 7 · 63.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled NO compared with control for respiratory failure in preterm infants
Population: respiratory failure in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death before discharge ‐ Studies with entry before 3 days based on oxygenation Inhaled NO vs control | RR 1.02 [0.89, 1.18] | 10 studies · 1066 participants | High |
Death before discharge ‐ Studies with entry after 3 days based on BPD risk Inhaled NO vs control | RR 1.18 [0.81, 1.71] | 3 studies · 1075 participants | High |
Death before discharge ‐ Studies of routine use in preterm infants on respiratory support Inhaled NO vs control | RR 0.9 [0.74, 1.1] | 4 studies · 1924 participants | Moderate |
Death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry before 3 days based on oxygenation Inhaled NO vs control | RR 0.94 [0.87, 1.01] | 8 studies · 958 participants | High |
Death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry after 3 days based on BPD risk Inhaled NO vs control | RR 0.92 [0.85, 1.01] | 3 studies · 1075 participants | High |
Death or bronchopulmonary dysplasia at 36 weeks ‐ Studies of routine use in preterm infants on respiratory support Inhaled NO vs control | RR 0.94 [0.87, 1.02] | 4 studies · 1924 participants | High |
Intraventricular haemorrhage (grade 3 or 4) ‐ Studies with entry before 3 days based on oxygenation Inhaled NO vs control | RR 1.2 [0.98, 1.47] | 6 studies · 773 participants | High |
Intraventricular haemorrhage (grade 3 or 4) ‐ Studies of routine use in preterm infants on respiratory support Inhaled NO vs control | RR 0.89 [0.73, 1.09] | 4 studies · 1913 participants | Moderate Downgraded: imprecision, inconsistency |
Neurodevelopmental disability ‐ Studies with entry before 3 days based on oxygenation Inhaled NO vs control | RR 1.05 [0.78, 1.4] | 2 studies · 208 participants | Moderate Downgraded: imprecision, inconsistency |
Neurodevelopmental disability ‐ Studies with entry after 3 days based on BPD risk Inhaled NO vs control | RR 0.9 [0.74, 1.09] | 2 studies · 498 participants | Moderate Downgraded: imprecision, inconsistency |
Neurodevelopmental disability ‐ Studies of routine use in preterm infants on respiratory support Inhaled NO vs control | RR 0.91 [0.74, 1.13] | 3 studies · 1223 participants | High |