Cochrane · systematic review · CD005949
Higher versus lower amino acid intake in parenteral nutrition for newborn infants
Osborn, DA, Schindler, T, Jones, LJ, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 71.4%Low 1 · 14.3%Moderate 0 · 0%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Higher versus lower amino acid intake in parenteral nutrition for newborn infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality to hospital discharge Higher vs lower amino acid intake | RR 0.9 [0.69, 1.17] | 14 studies · 1407 participants | Low Downgraded: imprecision |
Neurodevelopmental disability Higher vs lower amino acid intake | RR 1.04 [0.48, 2.23] | 2 studies · 201 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Postnatal growth failure at discharge (weight < 10th centile) Higher vs lower amino acid intake | RR 0.74 [0.56, 0.97] | 3 studies · 203 participants | Very low Downgraded: imprecision |
Weight gain to discharge (g/kg/d) Higher vs lower amino acid intake | no estimate extracted | 4 studies · 291 participants | Very low Downgraded: risk of bias, imprecision |
Head circumference growth to discharge (cm/week) Higher vs lower amino acid intake | no estimate extracted | 4 studies · 315 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Retinopathy of prematurity Higher vs lower amino acid intake | RR 0.44 [0.21, 0.93] | 4 studies · 269 participants | Very low Downgraded: imprecision |
Abnormal blood urea nitrogen (various criteria) Higher vs lower amino acid intake | RR 2.77 [2.13, 3.61] | 7 studies · 688 participants | High |